LayoutTests/fast/events/pointer-events-mutation.html

<style>
.none { pointer-events:none; }
</style>
<div class=target>target1</div>
<div><span class=target>target2</span></div>
<pre id=log></pre>
<script>
if (window.testRunner)
    testRunner.dumpAsText();

function test(target, expected) {
    const pass = document.elementFromPoint(target.offsetLeft + 5, target.offsetTop + 5) === expected;
    log.textContent += pass ? "PASS\n" : "FAIL\n"

}
for (target of document.querySelectorAll(".target")) {
    test(target, target);
    target.classList.add("none");
    test(target, target.parentElement);
    target.classList.remove("none");
    test(target, target);
}
</script>